- Publication date : 2018-01-01
Alzheimers Dement (N Y). 2018 Dec 10;4:677-687. doi: 10.1016/j.trci.2018.10.005. eCollection 2018.
3xTg-AD mice; Alzheimer's disease; Branched-chain amino acids; Dietary protein; Tau pathology
High levels of plasmatic branched-chain amino acids (BCAA), commonly used as dietary supplements, are linked to metabolic risk factors for Alzheimer's disease (AD). BCAA directly influence amino acid transport to the brain and, therefore, neurotransmitter levels. We thus investigated the impact of BCAA on AD neuropathology in a mouse model.